Effective Jan. 1, 2017, NCATS will no longer supply compounds and NIH Clinical Collection sets through its Small Molecule Repository (SMR). NCATS is processing SMR orders placed prior to Dec. 31, 2016, and investigators should expect delivery by no later than Jan. 31, 2017. The SMR website will remain accessible through Jan. 31, 2017, and then permanently shut down. NCATS thanks all who supported the SMR over the years.



Samples that pass QC are stored in automated storage equipment for fast retrieval. MLSMR uses a three-tier storage system: Long Term Store, Working Store, and Short Term Store.

MLSMR stores and handles all DMSO solutions of the compounds under nitrogen atmosphere to prevent water absorption. We've validated our process minimizes water absorption and haven't observed compound precipitation from the DMSO solutions.

Long Term Store (LTS)

MLSMR stores the bulk sample in glass vials. Long Term Store samples will be held for five to ten years in a Nexus BioSystems Universal Store, an automated sample storage and retrieval system.


Working Store (WS)

MLSMR creates a 10 mM DMSO solution Working Store sample of each compound to be stored and used for up to one year. We create the microtiter plates shipped to the MLPCN from the Working Store samples.

The Working Store samples are stored in polypropylene tubes in SBS 96 well format and can be individually moved to create variable well arrangements or cherry pick sets. When a Working Store sample is depleted, the sample is discarded and a new one is created from the Long Term Store.

MLSMR currently stores Working Store samples in a Nexus BioSystems Universal Store US-1500-PT2. Additionally, TekCel TubeStore system is used to store some samples for short term use.


Short Term Store (STS)

DMSO solution samples formatted in microtiter plates and ready for shipment to MLPCN are held in the Short Term Store. Short Term Store plates are typically created just in time and stored less than one week. But, some standard collections may be pre-plated and stored up to three months before shipment.
Tier Conditions Equipment Storage Capacity
Long Term Store -20 °C / nitrogen Nexus BioSystems Universal Store 1500 500,000 x 4 mL glass vials
Working Store -20 °C / nitrogen TekCel TubeStore 200,000 x 0.5 mL polypropylene tubes
Working Store -20 °C / nitrogen Nexus BioSystems Universal Store 1500-PT2 1,000,000 x 0.5 mL polypropylene tubes
Short Term Store -20 °C Warehouse freezers microtiter plates