Effective Jan. 1, 2017, NCATS will no longer supply compounds and NIH Clinical Collection sets through its Small Molecule Repository (SMR). Queries concerning NCATS compounds may be referred to email@example.com.
|MLSMR Project >
MLSMR processes all
received samples in a standard, high-throughput
Quality Control regimen that checks their weight,
solubility, identity, and purity.
- Sample weight is verified to ensure
that the minimum amount required was
- Sample solubility is checked in a
volatile solvent mixture, used to
prepare Working Store (WS) and LC-MS samples,
and DMSO, used for sample storage. MLSMR
accepts only completely soluble samples.
- We use LC-MS to determine sample
identity and purity using two Waters
eight-channel MUX instruments with
combined capacity to analyze one million
samples per year under a variety of
conditions. MLSMR accepts samples where the
molecular ion is identified and Area
Under the Curve (AUC) is at least 90% by
Evaporative Light Scattering (ELS) or
UV (at 214 nm) detection.