Effective Jan. 1, 2017, NCATS will no longer supply compounds and NIH Clinical Collection sets through its Small Molecule Repository (SMR). NCATS is processing SMR orders placed prior to Dec. 31, 2016, and investigators should expect delivery by no later than Jan. 31, 2017. The SMR website will remain accessible through Jan. 31, 2017, and then permanently shut down. NCATS thanks all who supported the SMR over the years.
|MLSMR Project >
MLSMR processes all
received samples in a standard, high-throughput
Quality Control regimen that checks their weight,
solubility, identity, and purity.
- Sample weight is verified to ensure
that the minimum amount required was
- Sample solubility is checked in a
volatile solvent mixture, used to
prepare Working Store (WS) and LC-MS samples,
and DMSO, used for sample storage. MLSMR
accepts only completely soluble samples.
- We use LC-MS to determine sample
identity and purity using two Waters
eight-channel MUX instruments with
combined capacity to analyze one million
samples per year under a variety of
conditions. MLSMR accepts samples where the
molecular ion is identified and Area
Under the Curve (AUC) is at least 90% by
Evaporative Light Scattering (ELS) or
UV (at 214 nm) detection.