Effective Jan. 1, 2017, NCATS will no longer supply compounds and NIH Clinical Collection sets through its Small Molecule Repository (SMR). NCATS is processing SMR orders placed prior to Dec. 31, 2016, and investigators should expect delivery by no later than Jan. 31, 2017. The SMR website will remain accessible through Jan. 31, 2017, and then permanently shut down. NCATS thanks all who supported the SMR over the years.

MLSMR processes all received samples in a standard, high-throughput Quality Control regimen that checks their weight, solubility, identity, and purity.

  • Sample weight is verified to ensure that the minimum amount required was received.
  • Sample solubility is checked in a volatile solvent mixture, used to prepare Working Store (WS) and LC-MS samples, and DMSO, used for sample storage. MLSMR accepts only completely soluble samples.
  • We use LC-MS to determine sample identity and purity using two Waters eight-channel MUX instruments with combined capacity to analyze one million samples per year under a variety of conditions. MLSMR accepts samples where the molecular ion is identified and Area Under the Curve (AUC) is at least 90% by Evaporative Light Scattering (ELS) or UV (at 214 nm) detection.