NIH Molecular Libraries
NIH Molecular Libraries Lab Assistant Evotec

Effective Jan. 1, 2017, NCATS will no longer supply compounds and NIH Clinical Collection sets through its Small Molecule Repository (SMR). NCATS is processing SMR orders placed prior to Dec. 31, 2016, and investigators should expect delivery by no later than Jan. 31, 2017. The SMR website will remain accessible through Jan. 31, 2017, and then permanently shut down. NCATS thanks all who supported the SMR over the years.

MLSMR uses aliquots of the Working Store solution in DMSO to create microtiter plates for delivery to the MLPCN. The screening centers choose from a range of delivery options including 96-, 384-, or 1536-well SBS plate formats.


The current compound quota is 450 nanomoles per screening center per year, not including material for hit follow-up. MLSMR delivers the full repository collection for standard screening to each center up to twice per year.
MLSMR stores and handles all DMSO solutions of the compounds under nitrogen atmosphere to prevent water absorption. We've validated our process minimizes water absorption and haven't observed compound precipitation from the DMSO solutions.